We approach the problem of shaping animals behavior by activity of neural networks from the prospective of innate behaviors. These basic behavioral patterns and their appropriate initiation and termination according to the availability of resources and environmental cues are crucial for physiological homeostasis. Aiming to understand the adaptive control of innate behaviors by specialized neuronal groups in the hypothalamus and we focus on their dynamic interactions and modulation by higher brain regions. We address this broad question for specific anatomical pathways and behaviors and apply state-of-the-art parallel unitary recording techniques in freely behaving rodents and optogenetics for cell-type- and projection-specific functional analysis. The goal of another research direction is to gain new insights into cellular and synaptic determinants of population neuronal activity. Various periodic synchronization regimes of cortical and hippocampal networks is an emergent physiological metric for neuronal dynamics in these regions, associated cognitive functions and disorders. In cooperative projects we investigate population neuronal activity in genetic mouse models to establish the contribution of specific membrane conductancies and network pathways to the generation of network oscillations in vivo.
Maier N, Morris G, Schuchmann S, Korotkova T, Ponomarenko A, Bohm C, Wozny C, Schmitz D (2012). Cannabinoids disrupt hippocampal sharp wave-ripples via inhibition of glutamate release. Hippocampus 22: 1350-1362.
Korotkova* T, Fuchs* EC, Ponomarenko A, von Engelhardt J, Monyer H (2010). NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory. Neuron 68: 557-569.
Racz* A, Ponomarenko* AA, Fuchs, EC, Monyer H (2009). Augmented hippocampal ripple oscillations in mice with reduced fast excitation onto parvalbumin-positive cells. J Neurosci 29: 2563-2568.
Wulff* P, Ponomarenko* AA, Bartos M, Korotkova TM, Fuchs EC, Bahner F, Both M, Tort AB, Kopell NJ, Wisden W, Monyer H (2009). Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons. Proc Natl Acad Sci U S A 106: 3561-3566.
Ponomarenko AA, Li JS, Korotkova TM, Huston JP, Haas HL (2008). Frequency of network synchronization in the hippocampus marks learning. Eur J Neurosci 27: 3035-3042.*-equal first author