We investigate the interaction between brain areas involved in tactile perception (somatosensory input), cognitive processing, and movement generation (motor output) in order to understand basic principles of the brain and ultimately to advance the design of neural prostheses. We address these research goals with behavioral tests and electrophysiological and optogenetic tools in the mammalian brain.
Diester I, Kaufman MT, Mogri M, Pashaie R, Goo W, Yizhar O, Ramakrishnan C, Deisseroth K, Shenoy KV (2011). An optogenetic toolbox designed for primates. Nat Neurosci 14:387-97.
Witten IB, Lin SC, Brodsky M, Prakash R, Diester I, Anikeeva P, Gradinaru V, Ramakrishnan C, Deisseroth K (2010). Cholinergic interneurons control local circuit activity and cocaine conditioning. Science 330:1677-81.
Gradinaru V, Zhang F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson KR, Deisseroth K (2010). Molecular, cellular, and genomic force multipliers for optogenetic control. Cell 141(1):154-65.
Diester I, Nieder A (2007). Semantic associations between signs and numerical categories in the prefrontal cortex. PLoS Biol 5(11):e294.
Nieder A, Diester I, Tudusciuc O (2006). Temporal and spatial enumeration processes in the primate parietal cortex. Science 313(5792):1431-5.