My present research focuses on sleep in humans and rodents and the role of sleep in memory consolidation including the involvement of neuromodulatory activity (e.g., 1-3). Our studies involve monitoring brain electric activity and performance in behavioral tasks. We are currently developing methods for measuring extracellular substrates within brain tissue and optogenetic manipulation of neuronal activity. Within the functional framework of sleep-associated memory consolidation and learning we have investigated the effects exerted by applied oscillatory and constant electric fields, as putative indicators of endogenous brain electric activity (4). Together with collaborators Prof. Lucas Parra at the City University of NY and Prof. Thomas Martinetz at the University of Lübeck we are investigating mechanisms through which applied weak oscillatory electric fields and currents modify neuronal network activity, sleep-dependent memory and homeostatic processes.
Ayoub A, Aumann D, Hörschelmann A, Kouchekmanesch A, Paul P, Born J, Marshall L (2013). Differential effects on fast and slow spindle activity, and the sleep slow oscillation in humans with carbamazepine and flunarizine to antagonize voltage-dependent na(+) and ca(2+) channel activity. Sleep 36:905-11-
Binder S, Baier, PC, Mölle M, Inostroza M, Born J, Marshall L (2012). Sleep enhances memory consolidation in the hippocampus-dependent object-place recognition task in rats. Neurobiology of Learning and Memory 97:213-9.
Kirov R, Weis C, Siebner, HR, Born J, Marshall L (2009). Wake slow oscillation electrical brain stimulation promotes EEG theta activity and memory encoding. Proc Natl Acad Sci U S A 106: 15460-5.
Marshall L, Helgadóttir H, Mölle M, Born J (2006). Boosting slow oscillations during sleep potentiates memory. Nature 444: 610-613.
Marshall L, Henze DA, Hirase H, Leinekugel X, Dragoi G, Buzsáki G (2002). Hippocampal pyramidal cell-interneuron spike transmission is frequency dependent and responsible for place modulation of interneuron discharge. J Neurosci 22: RC197.