Our department is interested in understanding the principles of cell-cell communication in the developing and mature nervous system. Neuronal circuit formation is dependent on the precise navigation of nerve cells (neurons) and their cellular processes (axons and dendrites) to their final destinations. Besides development, we are also interested in understanding how specific neuron populations contribute to certain types of behavior of adult mice. For these studies, we are using genetic methods to alter the circuitry in specific ways and correlate the changes in behavior with the activity of well-defined neuron populations. Combined with the functional dissection of the underlying circuitry and the synaptic connections of the participating neurons, we gain insight into how the brain works at the level of individual cell populations.
Gong J, Körner R, Gaitnaos L, Klein R (2016). Exosomes mediate cell contact-independent ephrin-Eph signaling during axon guidance. Journal of Cell Biology in press
Seiradake E#, del Toro D#, Nagel D, Cop F, Härtl R, Ruff T, Seyit-Bremer G, Harlos K, Border EC, Acker-Palmer A, Jones EY*, Klein R* (2014). FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron 84, 370-385 *corresponding authors, # equal contribution
Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R (2014). The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol 204(3): 409-22, doi: 10.1083/jcb.201305037
Gatto G, Morales D, Kania A, Klein R (2014). EphA4 receptor shedding regulates spinal motor axon guidance. Curr Biol 2014 Oct 20;24(20):2355-65
Paixao S, Balijepalli A, Serradj N, Niu J, Luo W, Martin JH, Klein R (2013). EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts. Neuron 80: 1407-1420