Our work focuses on in-vivo neurophysiological recordings of systems and neuronal activity in rodents implied in psychiatrically relevant mechanisms. Specifically, we study mechanisms of sleep-dependent cortico-hippocampal interactions putatively implied in memory formation and consolidation, memory being systematically affected in many neuropsychiaric disorders. Further, we record from (pre-)frontal areas in neuropsychiatric animal models looking for neurophysiological correlates of impaired prefrontal functions like working memory and decision generation. Our experimental approaches rely on computational neuroscience work in the sense that facing the complexity of in-vivo physiological phenoma and the size of the perameter space, as far as possible we try to do computational model-derived hypothesis testing.
Hahn TT, McFarland JM, Berberich S, Sakmann B, Mehta MR, (2012). Region specific, spontaneous persistent activity in the entorhinal cortex modulates cortico-hippocampal interactions in vivo. Nat Neurosci 15:1531-8
Bruno RM, Hahn TT, Wallace DJ, de Kock CP, Sakmann B (2009). Sensory experience alters specific branches of individual corticocortical axons during development. J Neurosci 29:3172-81.
Hahn TT, Sakmann B, Mehta MR (2007). Differential responses of hippocampal subfields to cortical up-down states. Proc Natl Acad Sci U S A 104:5169-5174.
Hahn TT, Sakmann B, Mehta MR (2006). Phase-locking of hippocampal interneurons' membrane potential to neocortical up-down states. Nat Neurosci 9:1359-1361.
Petersen CCH, Hahn TT, Mehta MR, Grinvald A, Sakmann B (2003). Interaction of sensory responses with spontaneous depolarisation in layer 2/3 barrel cortex. Proc Natl Acad Sci U S A 100:13638–13643.