Our group is interested in understanding the neural circuits underlying cognition and behavior and how these circuits are disrupted in psychiatric disease. To address this, we perform multi-site recordings of neural activity in mice performing behavioral tasks. These recordings are carried out both in healthy wild-type mice as well as in mice carrying genetic mutations that predispose to psychiatric illness in humans.
O'Neill P-K, Gordon JA, Sigurdsson T (2013). Theta Oscillations in the Medial Prefrontal Cortex Are Modulated by Spatial Working Memory and Synchronize with the Hippocampus through Its Ventral Subregion. J Neurosci 33(35):14211-24.
Burghardt NS, Sigurdsson T, Gorman JM, McEwen BS, LeDoux JE (2013). Chronic antidepressant treatment impairs the acquisition of fear extinction. Biol Psychiatry 73(11):1078-86.
Sigurdsson T, Stark KL, Karayiorgou M, Gogos, Gordon JA (2010). Impaired Hippocampal-Prefrontal Synchrony in a Genetic Mouse Model of Schizophrenia. Nature 464: 763-7.
Sigurdsson T, Cain CK, Doyere V, LeDoux JE (2010). Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo. Eur J Neurosci 31(2): 250:262.
Sigurdsson T, Doyere V, Cain CK, LeDoux JE (2007). Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory. Neuropharmacology 52(1):215-227.