We intend to understand and modulate cortical plasticity in man. This is mainly done on a behavioural, imaging and electrophysiological level. We use (motor) learning paradigms, evaluate them by behavioural techniques and by recording EMG; EEG or fMRI data in the context with connectivity analyses. We develop and/or apply stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation, alternating current stimulation or random noise stimulation (tDCS, tACS, tRNS). TMS induces a short electric current in the human brain. Both rTMS and electric stimulation techniques offer the prospect of inducing LTD and LTP like effects in the human brain. Diseases in our focus are Parkinson’s disease, epilepsy, migraine, stroke and dystonia. The Department of Clinical Neurophysiology pursues other research areas such as Neurorehabilitation in conjunction with the Bernstein Centre of Computational Neuroscience and with the Company Otto Bock. (overview researcher ID Walter Paulus A-3544-2009).
Paulus W, Peterchev AV, Ridding M (2013). Transcranial electric and magnetic stimulation: technique and paradigms. Lozano, A.M., Hallett, M., editors. Handbof Clin Neurol (3rd series); Brain Stimulation. Amsterdam: Elsevier, p 330-342.
Sommer M, Norden C, Schmack L, Rothkegel H, Lang N, Paulus W (2013). Opposite optimal current flow directions for induction of neuroplasticity and excitation threshold in the human motor cortex. Brain stimulation 6:363-70.
Moliadze V, Atalay D, Antal A, Paulus W (2012). Close to threshold transcranial electrical stimulation preferentially activates inhibitory networks before switching to excitation with higher intensities. Brain stimulation 5:505-11.
Polania R, Nitsche MA, Korman C, Batsikadze G, Paulus W (2012a). The importance of timing in segregated theta phase-coupling for cognitive performance. Curr Biol 22:1314-8.
Polania R, Paulus W, Nitsche MA (2012b). Modulating cortico-striatal and thalamo-cortical functional connectivity with transcranial direct current stimulation. Human brain mapping 33:2499-508.